Starship Troopers ipod A recent British study has found that the widely-used epilepsy drug Topamax® (topiramate) raises the risk of birth defects when taken by pregnant women. When combined with the drug valproate, the risk of the occurrence birth defects is even higher.
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The results are still statistically uncertain because the study included only 203 women, but experts were not surprised with the findings because Topamax has been shown to cause defects in animals.
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Of the 203 pregnancies in the study, 18 ended in spontaneous abortion, five in induced abortions, and two in stillbirths. Of the 178 babies born, 16 had major birth defects. In three of those cases, the mothers had only taken topiramate and the other 13 involved topiramate and other drugs. Cleft palates or lips were present in four of the babies, an occurrence 11 times the normal rate of 1 in 500 among women not taking epilepsy drugs. Four male babies had genital birth defects, up 14 times the normal rate of 1 in 300.
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Doctors urge epileptic women to continue taking the drug during pregnancy despite the enormous risks because of the danger of seizures on the unborn babies. Women who are taking the drug to prevent migraines should stop if they become pregnant or are planning to become pregnant.
